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post hoc test). doi:10.1371/journal.pone.0067730.gspontaneous nociceptive response (licking) with inhibitions of 38610 and 5467 , respectively, similar to the inhibition of 5367 of the positive control camphor. In the cold plate, S-(+)dicentrine (100 mg/kg) increased the latency time for paw withdrawal in 80613 , similar to the positive control camphor (84617 ). When administered by intraplantar
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risk in the future, after validation in long-term clinical studies. In addition, we aimed to validate this gene signature in experimental models of OSA, using mice and in vitro cell cultures exposed to IH. We hypothesized that the pattern of gene regulation in mouse aorta and EC exposed to IH is also exhibited in the skin vasculature of OSA patients.and healthy controls (AHI,10/h) (Table 1). Subje