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sf1 following stress adaptation Almost three decades ago, Lindquist and Didomenico et al. postulated that feedback elements exist to down-regulate the heat shock response. Initially, Hsp70 was proposed to become a essential repressor of Hsf1 activation, but later proof indicated that Hsp70 is in truth a prerequisite for Hsp90-dependent functions. Certainly, a role for Hsp90 in Hsf1 repression was
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